a Record control number WOS:000311607100017

a ISSN 1743-7555

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QZ200

b Item number .T57 2012

a Personal name Yagci-Kupeli, B

h Medium Electronic Document

a Title Tissue Doppler and myocardial deformation imaging to detect myocardial dysfunction in pediatric cancer patients treated with high doses of anthracyclines

c Statement of responsibility, etc Begul Yagci-Kupeli, Ali Varan, Hikmet Yorgun, Baris Kaya, Munevver Buyukpamukcu.

a Place of publication, distribution, etc New Jersey

b Name of publisher, distributor, etc Wiley-Blackwell,

c Date of publication, distribution, etc 2012.

a Summary, etc Aim To detect subtle changes in myocardial function in pediatric cancer patients treated with high dose anthracyclines.Methods In all, 19 pediatric cancer patients with no cardiotoxicity findings treated with a cumulative anthracycline dose of =350?mg/m2 and healthy participants of the same age were included in the study. Transthoracic echocardiography measurements, pulsed-wave tissue Doppler from the basal portions of all walls and strain and strain rate imaging of all walls from basal portion were obtained.Results A total of 19 patients (13 boys and six girls) and 17 participants (10 boys and seven girls) in the control group were enrolled. Three patients had subnormal ejection fraction (EF) and fractional shortening (FS) values. There was no significant difference in EF and FS between the two groups. The left ventricle isovolumic relaxation time was prolonged (P?=?0.02) and the mitral color propagation velocity was decreased in patients (P?=?0.001). Peak systolic strain and strain rates of the right ventricle, septal, lateral and inferior wall basal region of the left ventricle were significantly lower in patients than controls (all P?<?0.05). Tissue Doppler measurements of early and late diastolic myocardial velocities of the right ventricular free wall, lateral wall of left ventricle and septum, and peak systolic myocardial velocity of the left ventricle anterior wall were significantly lower in patients (all P?<?0.05).Conclusion Myocardial Doppler and deformation imaging techniques provide a thorough evaluation of cardiac functions with the advantage of detecting subtle early changes before a global cardiac functional impairment occurs.

a Topical term or geographic name as entry element Oncology

a Topical term or geographic name as entry element Anthracycline

a Topical term or geographic name as entry element Cardiotoxicity

a Topical term or geographic name as entry element myocardial deformation

a Topical term or geographic name as entry element Doppler imaging

a Topical term or geographic name as entry element Acute Lymphoblastic-Leukemia

a Topical term or geographic name as entry element Childhood-Cancer

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

g Relationship information DEC 2012, Vol.8 Issue 4, p368-374

t Title Asia-Pacific Journal Of Clinical Oncology

x International Standard Serial Number 17437555

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1111/j.1743-7563.2012.01566.x